Highly Divergent Profiles: For routing configurations that are not pre-calculated as common scenarios and whose costs vary too much from default configurations, the original A* algorithm might still be faster (and is often used as an automatic fallback).
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Finding these optimization opportunities can itself be a significant undertaking. It requires end-to-end understanding of the spec to identify which behaviors are observable and which can safely be elided. Even then, whether a given optimization is actually spec-compliant is often unclear. Implementers must make judgment calls about which semantics they can relax without breaking compatibility. This puts enormous pressure on runtime teams to become spec experts just to achieve acceptable performance.
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